VANCOUVER, British Columbia, Oct. 15, 2014 (GLOBE NEWSWIRE) — Tekmira Pharmaceuticals Corporation (Nasdaq:TKMR) (TSX:TKM), a leading developer of RNA interference (RNAi) therapeutics, announced today the presentation of preclinical results characterizing TKM-HBV, a therapeutic agent targeting human hepatitis B virus (HBV), at the 10th Annual Meeting of the Oligonucleotide Therapeutics Society. Tekmira’s Chief Technical Officer, Dr. Ian MacLachlan delivered a podium presentation titled, “Update on the Preclinical Development of an LNP-Based HBV Therapeutic.” The conference is taking place in San Diego, California, from October 12 – 15, 2014.
Among the results reported is the potent and rapid reduction in hepatitis B surface antigen (HBsAg) demonstrated by TKM-HBV in several preclinical models including the chronically infected humanized (chimeric) mouse.
“These results reflect the rigorous approach we have taken to the design and characterization of our novel hepatitis B therapeutic,” said Dr. Mark J Murray, President and CEO, Tekmira Pharmaceuticals. “TKM-HBV employs a unique combination of three RNAi triggers, in a third generation LNP formulation, which results in broad and effective knockdown of viral mRNAs and viral proteins including hepatitis B surface antigen, our primary therapeutic target. This data supports the utility of TKM-HBV as a new therapeutic option for treating patients with chronic HBV infection. Our plan is to file an IND, or equivalent document, by the end of this year, and initiate clinical trials in early 2015.”